in a word...don't. lol
In seriousness, I do a trip about once a year that's 800 miles each way. I'll do about 650 in a day, so I drive that far, crash at a friends house, and then we caravan the rest of the way the next day. On the way home, I split it about halfway so it's 400 each day.
I'm in a soft top with soft upper doors, so the wind noise is pretty tiring. I wear ear plugs and crank the radio so I can hear the music through them. That helps a lot. I also plan my route around avoiding interstates whenever possible so no one expects me to exceed 65mph. There's a lot of difference in noise level from 65 to 75.
If I trusted the 160k mile 4L60E in my pickup just a little more, I would flat tow that 650 miles 11 times out of 10.
My 4l60e has 243k miles and 32 years of boat towing on it. You can do it.