I agree 4" works well and is probably the ideal no-problem amount of backspacing for 33 or 35x12.50 tires.
If you need the tires tucked in an extra half-inch you can run 4.5" of backspacing but you'll have to add a washer or two under both of the steering stop bolts. Those would serve to stop the tires from rubbing on the lower control arms when the steering wheel is turned all the way left or right with that much backspacing. I successfully ran 4.5" for a couple years after installing the two pairs of washers. They didn't increase the turning radius enough to notice, I kept them in place after replacing those wheels with a different set with 3.75" of BS.
One thing that's good about slightly restricting how far the steering wheel can be turned with the addition of the two pairs of washers is that it removes some of the stress placed on the u-joints and their 'ears' in the axle shafts that hold them. It's when the steering is turned hard either direction that the most pressure against the u-joint ears on the axle shafts occurs which can result in breakage if you're in a tough wheeling situation. That's how I broke my passenger-side axle shaft, giving it a little too much gas during a hard/max turn while in 4Lo.