Using foam gap filler in frame?

a closed cell foam might work. Closed cell foams do not absorb water.

What I’ve seen in the real world is even those closed cell foams hold water/moisture against a surface. So while the foam itself may not absorb the water/moisture, it will create voids and hold water/moisture that finds its way in. You can see this in a lot of houses that have been sprayed, predominately in older houses that were not sealed as tight as some of the new ones.
 
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What I’ve seen in the real world is even those closed cell foams hold water/moisture against a surface. So while the foam itself may not absorb the water/moisture, it will create voids and hold water/moisture that finds its way in.
I can verify from many years of personal experience that closed cell neoprenes can definitely soak up water. Of course some closed cell products don't but....
 
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I don't understand why people even think about using crap from a hardware store or that they have laying around. Companies like 3M, PPG, Eastwood and others have extremely well engineered products specifically for repairing, coating, and preserving vehicles. Cavity wax is just one example.