It's a personal preference. I know people running 33s with 3.73 gearing and it doesn't bother them at all. I always turned the OD off on my 42rle trans Jeeps for highway use.
Just one TJ and a WJ I bought for my wife, right now. I've bought too many.
p.s. My wife loves loud MT tires, so I had to buy her some. Now she wants me to lift it. Still cheaper than buying her shoes.