After the drive around flush with Prestone for a couple of days, then we do the Thermocure. If you leave that in too long, the black is harder to flush out. After a day or so, maybe two, then we pull the thermostat and put the housing back on. We start by filling with tap water and starting the engine to circulate that for 10 minutes roughly. We keep doing that until the drained water is clean and clear into a clean white or light colored bucket. When it is clean, then we do two full flushes with distilled. Drain that, install new thermostat that has a 1/8" hole drilled next to the jiggler. Fill with coolant pre-mix of 1/3 distilled to 2/3 coolant. Start and circulate until we see the coolant movement in the radiator that shows the thermostat has opened, install radiator cap, top off overflow reservoir to the full level.
We have never pulled the block drain and never will.