So what's the trade off with aftermarket tunes? More emissions? There is no free lunch usually with these type of things ..
For my Colorado, I've noticed a couple of things with the tune. the 1-2 shift is more noticeable, i.e. firmer than factory. Sometimes, if I rush the "start up" the engine will rev. What I mean by that is if I fire up the truck in the morning and don't wait a few seconds (like 30), before shifting into reverse, the engine will rev before the transmission catches up. The sole reason I bought the tune is that in certain situations, my truck would not cruise in overdrive on the highway (hold 7th), or it would hunt between 7 and 8 gear. I took it in for warranty, the dealership confirmed the "issue" but also told me it was a non-issue. So, I purchased the tune. It fixed that problem by creating a bit more torque and power and adjusting shift points. I tried the 350 dollar solution before I went down the path of re-gearing. Glad I did.
The tune, from what I understand, bumps timing a little bit, leans out the maps a little. They recommend Premium Fuel, so they are probably advancing the timing quite a bit and relying on the knock sensor more than OEM would. I've run it both ways. Premium will perform better. When I first installed the tune, I did some "testing" using the Ulysses GPS app. I pulled a 7.x second 0-60 run. Factory is over 8 seconds. I don't remember the quarter mile times, but it was also impressively fast for a lifted pickup truck with "only" a V6.
Additionally, I return about 1.5 MPG better, on average, running the tune...so far. Now, I will need to run it through the winter to really tell. I installed the tune in march this year, right about the same time they go from winter to summer blend in Michigan. The mileage improvement could be related to that.