Not without knowing the rpm's you are turning at hwy cruise speeds...this is the main contributor. One can skew results by having a foot in the gas pedal constantly, but I doubt this is the case if you manage 14mpg in city driving.
Since I get 12 no matter what speed or gear, I somehow don't think RPMs are the answer.
I found out the hard way the mileage I was getting on the highway.
Several years ago, I took a road trip to Ohio from Arizona. I knew I was getting the 14 in the city, so I was anticipating at LEAST 15 or 16 on the highway. Nope. 11 to 12. This was 70 in 5th. I tried running at 65 for a tank full. Then I tried 70. Then 75. Then 60. I tried both 4th and 5th. No change.
While on the trip, I asked on this and a couple other forums what the problem could be. I got varying answers, but the most promising seemed to be O2 Sensors. When I got home, I changed them. Nothing. 12 MPG. Air filter. TPS sensor. And so on. No change. For a while, I was only getting 12 MPG here in town! But it went back up to 14 before too long.
The following year, I again made the same trip, figuring that with all I had done, I should be able to get better mileage. Nope. STILL 12.
I don't know what the answer might be. I have talked to several experienced mechanics and have discussed it on the forums. NOBODY has been able to give me an idea of where to even LOOK for a clue after all I've done to try to correct the problem. Everything that anybody's suggested I've tried. So I just don't road trip The Muddog any more.
The truck is more comfortable for a road trip any way.