I run the Midland MXT275 GMRS, and have had good luck with it. All the controls are in the handset, and you can mount the box just about anywhere.
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I mounted the box up under the dash in the driver's side footwell. I also have a similar type CB, the Cobra 75, mounted up there as well.
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The mic hangs on the dash, and has a remote plug (RJ45, iirc) which is easy to disconnect when necessary.
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I ditched the small antenna which comes with the unit, and installed a Laird antenna. A good antenna makes all the difference.
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I also run a remote speaker, which I mounted above the rearview mirror, which makes a big difference in sound.