certainly after 200,000 maybe around 150,000. I see these people all the time that are trying to sell their cars quickly because they just rolled over 1000,000, nothing wrong with them, just don't want a "high mileage" car. My household has 5 running cars, not one of them under 100,000. and I go to pick up my friends that are stranded on the side of their road in their brand new whatever all the time.
'01 Jeep: 260,000 - runs fine, general maintenance required but is my reliable daily.
2000 - 4 runner : 160,000. the runt of the bunch, but has never let me down and takes little maintenance
'99 Maxinma : 180,000 - running strong
'04 Sonata : 240,000 - should have died years ago, is basically dead now, but somehow still starts and drives
'66 VW Dunebuggy : 327,000 (ish, no one knows for sure) been rebuilt a few times and rolled over a few times never left me stranded and has made for a great car to learn to work on and will always make you smile.
I would say that all of my family's cars are "high milage" but they sure seem to be a lot more reliable than the cars I see that just rolled off the lot.