The calculator is helpful for determining driveshaft speeds, but the transmission and OD ratios matter for everyday practical driving.Also, if you gear to high (low number like 3.73 or 4.10) your drive shaft as well as your engine and everything else upstream from the pinion is going to have less of a mechanical advantage. This means they will have to work harder to move your Jeep forward, this puts more strain on things and makes you more likely to break a drive shaft when off-roading.
To answer your question more directly though @CHAWK I personally think you will be better suited with 4.56 and think 4.88 is too low (high number) for your tire diameter. 4.88 is what I'd expect if someone is running 37" tires. The problem with recommendations is often that people assume that they know what your needs and goals are, they might assume you are building your jeep for off-roading only. It is nuanced, and what is best for you is not necessarily what is best for the next guy. Either that or people don't understand what they are recommending in the first place.
I have the 6-speed and 456 gears which I set up for 33’s. Shaft rpm’s at 60 according to your calculator are 2787. I could pull the long gradual hills in ID and have power to spare. My mpg averaged 13. I went to 35’s and most of those hills I need to downshift to keep speed. My mpg reduced to 11.
According to the calculator and recommended 2500rpm I should be running 37’s. I can’t imagine the drag that would be.
Bottom line. There are other factors besides driveshaft speed that should be considered.
At what shaft rpm would you see inevitably causing vibes?