I'd look at your drive shafts and be sure all the Ujoints are good and tight. Same for the front axle Ujoints. As said, fluids and filters are key. A new drive belt and idler and tensioner pulley are a good idea. Steering good and tight.
What was so miserable about that last roadtrip? Other than ending up in NY I mean.

Have a decent tool kit and some spare parts in the back. Try and be as light as possible, but still have what you may need. Don't forget the fire extinguisher.
Be sure to get plenty of pics to share. Enjoy.